Diabetes Talking

Question:

What is MDI?

Multiple Daily Injections. It’s another TLA (Three Letter Acronym)…

Response:

Hmmm, although to be completely accurate I should be saying MDJ (Multiple Daily Jetting). When is an Injection not an Injection? Philip Martin.

– Hide quoted text — Show quoted text – What is MDI? Multiple Daily Injections. It’s another TLA (Three Letter Acronym)…

Response:

Martin You might be interested in the AIDA diabetes simulator program – lots of technical information, insulin curves and differential equations (if you’re interested), and you can try out the effects of insulin timing and meals with graphical results.  Look at http://www.2aida.org/ Philip

Response:

thanks… so obvious now… Mart

– Hide quoted text — Show quoted text – Multiple Daily Injections — RK [T1 that was smarter then her previous Doctors!][dx'd 5/00][Lantus Lover w/Novolog] http://www.zerolimit.net/files/zl-mirc.exe (#diabeticnet chatroom software) What is MDI? Martin. Hi Martin, Well I don’t know about a lot of insulin. I go 250 lbs and take up to 40 units of Actrapid a day and 40 units of Insulatard. Your equivalent is something like 28 Actrapid and 68 Insulatard. If I recall correctly, Mixtard 30 is basically a blend of these two. One of the reasons they changed me over to Basal Bolus was because of the high level of Mixtard I was having to use to keep my numbers down. The other reason was that I became allergic to one of the carriers in the Mixtard! To be honest, changing over to MDI was one of the best things I have done, I can now eat more normally, adjusting my insulin to what I am about to eat and my numbers run between 4.5 and 8:-) I also feel one hell of a lot better in myself, more energy and a lot less sleeping in the evening. I have also been the Metformin route, bloody stuff! It really gave my the jip, constant stomach upsets and pain. I spent most of my oral time on Tolbutamide and then the addition of Avandia, which was good whilst it lasted but my GP recons my pancreas has started to give up the ghost, hence the change to insulin. Philip Martin. Happily Insulin Jetting.

Response:

I’m not sure of the UK versions as to US.. But you might ask for Humulin U as your background (basal)(since Lantus isn’t available in the UK yet) and NovoRapid(US-Novolog) for the meal insulin(bolus) — RK [T1 that was smarter then her previous Doctors!][dx'd 5/00][Lantus Lover w/Novolog] http://www.zerolimit.net/files/zl-mirc.exe (#diabeticnet chatroom software)

– Hide quoted text — Show quoted text – Thanks for your reply, Well this is where I’m at now.  The diabetic nurse had a chat with me today to find out how I’m doing.  Basically the regular part of the mix is not doing enough in the mornings, so I have been increasing it.  However the NPH part of the mix is working well and I’m tending to almost a hypo later on in the day.  I find the mix very restrictive. She suggested that I might want to try going on to Humalin and a different insulin for background, but I should be aware that this means 4 injections, 1 per meal and 1 for the background.  Well, I don’t care about the injections, but my average bg is still a little high in the 10s (180). She has suggested that as I am skipping breakfast ( because i’m too high already on waking) I cycle the seven miles to Uni, then inject at about 10 ish which should be ok for my lunch at 1.00 (a reduced 40 units). Then for evening inject again at say 5.30 50u for the evening. I don’t really see what this is intended to do!  Maybe if there is an insulin chart I can see where the peaks are *supposed* to be… Martin Martin Hi Martin, Well I don’t know about a lot of insulin. I go 250 lbs and take up to 40 units of Actrapid a day and 40 units of Insulatard. Your equivalent is something like 28 Actrapid and 68 Insulatard. If I recall correctly, Mixtard 30 is basically a blend of these two. One of the reasons they changed me over to Basal Bolus was because of the high level of Mixtard I was having to use to keep my numbers down. The other reason was that I became allergic to one of the carriers in the Mixtard! To be honest, changing over to MDI was one of the best things I have done, I can now eat more normally, adjusting my insulin to what I am about to eat and my numbers run between 4.5 and 8:-) I also feel one hell of a lot better in myself, more energy and a lot less sleeping in the evening. I have also been the Metformin route, bloody stuff! It really gave my the jip, constant stomach upsets and pain. I spent most of my oral time on Tolbutamide and then the addition of Avandia, which was good whilst it lasted but my GP recons my pancreas has started to give up the ghost, hence the change to insulin. Philip Martin. Happily Insulin Jetting.

Response:

Multiple Daily Injections — RK [T1 that was smarter then her previous Doctors!][dx'd 5/00][Lantus Lover w/Novolog] http://www.zerolimit.net/files/zl-mirc.exe (#diabeticnet chatroom software)

– Hide quoted text — Show quoted text – What is MDI? Martin. Hi Martin, Well I don’t know about a lot of insulin. I go 250 lbs and take up to 40 units of Actrapid a day and 40 units of Insulatard. Your equivalent is something like 28 Actrapid and 68 Insulatard. If I recall correctly, Mixtard 30 is basically a blend of these two. One of the reasons they changed me over to Basal Bolus was because of the high level of Mixtard I was having to use to keep my numbers down. The other reason was that I became allergic to one of the carriers in the Mixtard! To be honest, changing over to MDI was one of the best things I have done, I can now eat more normally, adjusting my insulin to what I am about to eat and my numbers run between 4.5 and 8:-) I also feel one hell of a lot better in myself, more energy and a lot less sleeping in the evening. I have also been the Metformin route, bloody stuff! It really gave my the jip, constant stomach upsets and pain. I spent most of my oral time on Tolbutamide and then the addition of Avandia, which was good whilst it lasted but my GP recons my pancreas has started to give up the ghost, hence the change to insulin. Philip Martin. Happily Insulin Jetting.

Response:

What is MDI? Martin.

– Hide quoted text — Show quoted text – Hi Martin, Well I don’t know about a lot of insulin. I go 250 lbs and take up to 40 units of Actrapid a day and 40 units of Insulatard. Your equivalent is something like 28 Actrapid and 68 Insulatard. If I recall correctly, Mixtard 30 is basically a blend of these two. One of the reasons they changed me over to Basal Bolus was because of the high level of Mixtard I was having to use to keep my numbers down. The other reason was that I became allergic to one of the carriers in the Mixtard! To be honest, changing over to MDI was one of the best things I have done, I can now eat more normally, adjusting my insulin to what I am about to eat and my numbers run between 4.5 and 8:-) I also feel one hell of a lot better in myself, more energy and a lot less sleeping in the evening. I have also been the Metformin route, bloody stuff! It really gave my the jip, constant stomach upsets and pain. I spent most of my oral time on Tolbutamide and then the addition of Avandia, which was good whilst it lasted but my GP recons my pancreas has started to give up the ghost, hence the change to insulin. Philip Martin. Happily Insulin Jetting.

Response:

Thanks for your reply, Well this is where I’m at now.  The diabetic nurse had a chat with me today to find out how I’m doing.  Basically the regular part of the mix is not doing enough in the mornings, so I have been increasing it.  However the NPH part of the mix is working well and I’m tending to almost a hypo later on in the day.  I find the mix very restrictive. She suggested that I might want to try going on to Humalin and a different insulin for background, but I should be aware that this means 4 injections, 1 per meal and 1 for the background.  Well, I don’t care about the injections, but my average bg is still a little high in the 10s (180). She has suggested that as I am skipping breakfast ( because i’m too high already on waking) I cycle the seven miles to Uni, then inject at about 10 ish which should be ok for my lunch at 1.00 (a reduced 40 units). Then for evening inject again at say 5.30 50u for the evening. I don’t really see what this is intended to do!  Maybe if there is an insulin chart I can see where the peaks are *supposed* to be… Martin Martin

– Hide quoted text — Show quoted text – Hi Martin, Well I don’t know about a lot of insulin. I go 250 lbs and take up to 40 units of Actrapid a day and 40 units of Insulatard. Your equivalent is something like 28 Actrapid and 68 Insulatard. If I recall correctly, Mixtard 30 is basically a blend of these two. One of the reasons they changed me over to Basal Bolus was because of the high level of Mixtard I was having to use to keep my numbers down. The other reason was that I became allergic to one of the carriers in the Mixtard! To be honest, changing over to MDI was one of the best things I have done, I can now eat more normally, adjusting my insulin to what I am about to eat and my numbers run between 4.5 and 8:-) I also feel one hell of a lot better in myself, more energy and a lot less sleeping in the evening. I have also been the Metformin route, bloody stuff! It really gave my the jip, constant stomach upsets and pain. I spent most of my oral time on Tolbutamide and then the addition of Avandia, which was good whilst it lasted but my GP recons my pancreas has started to give up the ghost, hence the change to insulin. Philip Martin. Happily Insulin Jetting.

Response:

Hi, I should know this but I don’t really understand it.  I’m a type 2 injecting 48u of Human Mixtard morning and and another 48 units in the evening (sounds a lot I think but I’m 220 pounds)! I understand that it is 30% regular and 70% NPH, and that regular is a quite fast insulin and NPH is a much slower one.  How does this translate into effect over time?  I usually have my morning shot at 8.30 – 9am and my evening one at 5.30pm. The insulin isn’t my choice (being totally ignorant means I have to rely on my endo and diabetic sister) but it is the first one I’ve been put on. With a waking bg of 11mmls/l (200) I skip breakfast (except coffee) and I have a half milk coffee around 10.30 and I’m usually about 4-5 mmols/l (90) by lunch.  I tend to have a sandwich or lunch and that puts me up to about 12 mmols by 2hrs PP (although obviously it depends on lunch), but I’m down to 5-6 mmols/l by about 5 ish. I intend to make a serious attempt to improve my diet and try and  make it work with my insulin! Second thing (unrelated).  Al has mentioned to me about the cholesterol/triglyceride drugs and anti resistance drugs.  Anyone know anything about them (side effects and effetiveness)?  I have tried metformin before I started insulin and it was good but caused a sharp rise in my Gamma GT (a liver test indicating possible but unspecified reaction to the metformin apparently) .  This has meant I was taken off it. Thanks all Martin Boulger

Response:

Hi Martin, Well I don’t know about a lot of insulin. I go 250 lbs and take up to 40 units of Actrapid a day and 40 units of Insulatard. Your equivalent is something like 28 Actrapid and 68 Insulatard. If I recall correctly, Mixtard 30 is basically a blend of these two. One of the reasons they changed me over to Basal Bolus was because of the high level of Mixtard I was having to use to keep my numbers down. The other reason was that I became allergic to one of the carriers in the Mixtard! To be honest, changing over to MDI was one of the best things I have done, I can now eat more normally, adjusting my insulin to what I am about to eat and my numbers run between 4.5 and 8:-) I also feel one hell of a lot better in myself, more energy and a lot less sleeping in the evening. I have also been the Metformin route, bloody stuff! It really gave my the jip, constant stomach upsets and pain. I spent most of my oral time on Tolbutamide and then the addition of Avandia, which was good whilst it lasted but my GP recons my pancreas has started to give up the ghost, hence the change to insulin. Philip Martin. Happily Insulin Jetting.

Response: