Diabetes Talking

Question:

So, let’s see if some of you non-chemistry impaired types can answer this one… It seems to me that Lispro will be too fast for me to use in my pump. Regular insulin is too slow.  What would the result be from mixing them?  Would there       be a bad interaction, or will one end up with an insulin with moderated characteristics?

I would be very leary of mixing Lis-Pro with ANY other form of insulin. However I’ll let Speaker go into details as I strongly suspect he can teach me a thing or fifty about it in his spare time. I do question why it’s too fast for your pump however.  Seems a minor change of schedule should work with a pump.  However,  Not a pump expert —          "Nothing adds excitement to your life like something          that is clearly none of your business!"     Battista

Response:

So, let’s see if some of you non-chemistry impaired types can answer this one… It seems to me that Lispro will be too fast for me to use in my pump. Regular insulin is too slow.  What would the result be from mixing them?  Would there   be a bad interaction, or will one end up with an insulin with moderated characteristics? What do you think, Speaker?  Others?            

Response:

Actually, the article that was written in the Diabetes Care Journal (a professional manual)  on testing LysPro stated that the best use of the Lyspro insulin was when it was mixed with regular insulin. The best results for straight lyspro insulin was when used with quickly digested carbos.         Low Fat < 10%  Lyspro worked best taken straight.         Medium fat 30%-40% diets lyspro/regular in a 50/50 mixture             worked best here.         Heavy fat diets (50%) there were insulin reaction occuring             when lyspro was taken with only.  Best results were splitting             the regular dose as 30 minutes prior and the remainder 1/2             hour after the meal.   Heavy fat is like thin crust             pizza, or a pint of Ben & Jerry’s Ice Cream.   The results were evaluated based on requiring more food/insulin to correct BGs.  Resulting in better control overall.   Many of the subjects in the study had BG that were out of control from the start.  Through the education and adapting a new routine their control improved across the board.  Which I thought was somewhat misleading results. Rick

Response: