Diabetes Talking

Question:

A monozygotic twin, whose twin is a type 1 diabetic, has a 30-50% risk. — Charly Coughran

Therefore there is more to TYPE I diabetes than just genetics

Response:

Double – Hide quoted text — Show quoted text – whats the incidence of type I diabetes in twins?

Response:

A monozygotic twin, whose twin is a type 1 diabetic, has a 30-50% risk. Therefore there is more to TYPE I diabetes than just genetics

The standard picture of auto immune type 1 diabetes, about 80% of type 1, is that an individual has a genetic predisposition to the disease.  Environmental circumstances then occur which trigger the disease.  The genetics of the predisposition are complex, involving multiple genes.  Some have been identified, some have not.  There are even genes which appear to be protective to some degree.  Even though there are families with strong, clear histories of diabetes, the majority of type 1 diabetics do not have a close relative with the disease. There are probably a fairly large number of environmental triggers.   One, congenital rubella infection, is pretty clearly established, many others are implicated with varying degrees of evidence.  The length of time from environmental trigger to overt disease is thought to be long, several months to many years, which makes it difficult to get a good handle on the culprits. — Charly Coughran

Response:

whats the incidence of type I diabetes in twins?

Response:

whats the incidence of type I diabetes in twins?

The risk of type I diabetes for twins is the same as that for the general population, 0.5%, but I suspect that is not the question you are asking. A dizygotic twin, whose twin is a type 1 diabetic, has a risk of 5%, the same as if he has a sibling other than a twin or a parent with type 1. A monozygotic twin, whose twin is a type 1 diabetic, has a 30-50% risk. — Charly Coughran

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